Test-ActiveSyncConnectivity – 403 Forbidden at ‘Issue an HTTP OPTIONS command’

I have spent some time troubleshooting an alert from SCOM that ActiveSync was not working on all Exchange 2010 servers in an environment. The environment is currently in co-existence with Exchange 2016, with all client access services already pointed to 2016. Running the Test-ActiveSyncConnectivity cmdlet returned the following result:

The odd thing was that
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